Ammonia → 2,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid amide

HRID 1155971Notes

Reaction equation

HRID 1155971 reaction equation
[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11](Cl)=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1.[NH3:15]>>[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11]([NH2:15])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 545007362,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid chloride

Product 1

HCID 540896312,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid amide

Procedure

The product of stage (b) (4.2 g) was added dropwise to excess aqueous ammonia with stirring and ice cooling. After 1 hour the white precipitate was filtered off and recrystallised from ethanol to give 1.1 g of title product, mp 136°-138° C.

Workup

  1. filtrationAfter 1 hour the white precipitate was filtered off
  2. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-1bf2508ee087481386050f91d455139e
Source dataset
uspto-grants-1982_06
Patent number
US04333759

Reaction notes

Loading…