Acetone → HCID 20536200, compound

HRID 1155979Notes

Reaction equation

HRID 1155979 reaction equation
Cl[CH:2]1[C:6]([CH3:8])([CH3:7])[C:5]2[CH:9]=[C:10]([C:13]#[N:14])[CH:11]=[CH:12][C:4]=2[O:3]1.CC(C)=[O:17]>O>[C:13]([C:10]1[CH:11]=[CH:12][C:4]2[O:3][CH:2]([OH:17])[C:6]([CH3:8])([CH3:7])[C:5]=2[CH:9]=1)#[N:14]

Participants

4

Reactant 2

HCID 180AcetoneHCID 205362092-Chloro-5-cyano-2,3-dihydro-3,3-dimethylbenzofuran

Product 1

HCID 20536200HCID 20536200, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product of Example 45 (2 g) was boiled under reflux in water (5 ml) and acetone (15 ml) for 31/2 hours. The product was then extracted into diethyl ether, the extracted solution then being washed twice with water, dried over sodium sulphate and run down under vacuum to give 1.7 g of crude product. Recrystallisation from toluene gave pure title product (1.3 g), mp 127°-129° C.

Workup

  1. custom2 hours
  2. extractionThe product was then extracted into diethyl ether
  3. washthe extracted solution then being washed twice with water
  4. dry with materialdried over sodium sulphate
  5. customto give 1.7 g of crude product
  6. customRecrystallisation from toluene

Sources & evidence

ORD record
ord-00febc41a04c4367a6b414c8ad7192da
Source dataset
uspto-grants-1982_06
Patent number
US04333759

Reaction notes

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