反应详情

A mixture of 4.2 g of imidazo-[1,2-a]-quinoline-2-methanol, 16.0 g of manganese dioxide and 11 ml of chloroform was refluxed for 4 hours and was then cooled overnight. The mixture was filtered through cellulose powder and the filter was washed with chloroform. The filtrate was evaporated to dryness under reduced pressure and the residue was triturated with diethyl ether to obtain 3.4 g of imidazo-[1,2-a]-quinoline-2-carboxaldehyde in the form of needles melting at 184°-185° C. after crystallization from an etherchloroform mixture.

1. temperaturewas refluxed for 4 hours
2. temperaturewas then cooled overnight
3. filtrationThe mixture was filtered through cellulose powder
4. washthe filter was washed with chloroform
5. customThe filtrate was evaporated to dryness under reduced pressure
6. customthe residue was triturated with diethyl ether