HCID 20523603, compound → HCID 13036383, compound

Participants

Reaction Steps

A mixture of 2-[4-(2-cycloheptimidazolyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine hydrochloride (1.0 g, described in Example 2) and 5% rhodium on carbon (0.10 g) in methanol (600 ml) was hydrogenated under an atmosphere of hydrogen at 50 lb/sq. in. pressure. The mixture was filtered and the filtrate was evaporated. The residue was dissolved in methanol and the solution was acidified with a few drops of 2 N hydrochloric acid. Acetone was added and crystals of the title compound were collected (0.880 g); mp>250° C.; ir (nujol) 3340 and 3160 cm-1 ; uv max (MeOH) 250 (ε=56500), 330 (ε=8200) and 342 nm (ε=7850); and nmr (DMSO-d6) δ 1.65 (m, 6H), 2.6 (m, 4H), 3.75 (m, 4H), 3.85 (s, 6H), 4.05 (m, 4H), 7.7 (s, 1H) and 7.75 (s, 1H).

Provenance & Evidence