HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 22820399, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 22820402 | HCID 22820402 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | HCID 22820399 | HCID 22820399 | — |
Reaction Steps
A solution of 7.8 g of 17β-hydroxy-16α-methyl-4,9(10)-estradien-3-one in 25 ml of pyridine and 8 ml of acetic anhydride is stirred for 6 hours at 50° C. under argon. After cooling the mixture is poured into saturated NaHCO3 solution and extracted with ethyl acetate. The ethyl acetate extracts are washed in succession with water, 2 N hydrochloric acid, and saturated NaCl solution, dried over sodium sulfate, and concentrated. Crystallization from ether yields 6.6 g of 17β-acetoxy-16α-methyl-4,9(10)-estradien-3-one, m.p. 124°-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333928 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-5bd2dc93a6f04c179b51f27da75504bd |
| Source note | uspto-grants-1982_06 |