HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156045Generated: October 30, 2026
tert-Butoxy bis(dimethylamino)methane → 16-Dimethylaminomethylene-3-methoxy-18-methyl-1,3,5(10)-estratrien-17-one
https://huagongshe.com/reaction/1156045
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | Ethylmetrienone | HCID 11087833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 16-Dimethylaminomethylene-3-methoxy-18-methyl-1,3,5(10)-estratrien-17-one | HCID 70545446 | 89.5% |
Reaction Steps
A mixture of 10 g of 3-methoxy-18-methyl-1,3,5(10)-estratrien-17-one and 15 g of bis(dimethylamino)tert.-butoxymethane is stirred for 3 hours at 160° C. After cooling the mixture is combined with 50 ml of ethanol and left at -5° C. for crystallizing purposes. After filtering off and drying, 10.6 g of 16-dimethylaminomethylene-3-methoxy-18-methyl-1,3,5(10)-estratrien-17-one is obtained, m.p. 157°-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04333928 |
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| Source dataset | uspto-grants-1982_06 |
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| ORD ID | ord-081aed428f294c768b0faacee172379b |
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| Source note | uspto-grants-1982_06 |
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