HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Fluoro-4-(hexadecylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Methyl 2-fluoro-4-hexadecylaminobenzoate | HCID 20536430 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Fluoro-4-(hexadecylamino)benzoic acid | HCID 20536411 | — |
Reaction Steps
A mixture of 3.5 g of methyl 2-fluoro-4-hexadecylaminobenzoate, 40 ml of ethanol, 60 ml of water, and 3.8 g of potassium hydroxide is heated on a steam bath for 14 hours. The hot solution is acidified with concentrated hydrochloric acid. The reaction mixture is cooled and filtered. The colorless residue is recrystallized from chloroform-hexane to yield 2-fluoro-4-(hexadecylamino)benzoic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333940 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-ee7ba911f8b04d27a35cf6dae521ad0e |
| Source note | uspto-grants-1982_06 |