HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2,3-Dihydroxypropyl 2-fluoro-4-(hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Iodo-1,2-propanediol | HCID 92127 | — |
| Reactant | 2-Fluoro-4-(hexadecylamino)benzoic acid | HCID 20536411 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | 2,3-Dihydroxypropyl 2-fluoro-4-(hexadecylamino)benzoate | HCID 20536504 | — |
Reaction Steps
A solution of 7.34 g. of 2-fluoro-4-(hexadecylamino)benzoic acid, 4.80 g. of 25% aqueous sodium hydroxide, and 12.6 g. of 3-iodo-1,2-propanediol in 50 ml of hexamethylphosphoramide is stirred for 24 hours at ambient temperature, diluted with 100 ml of ether and stirred for 5 days at ambient temperature. The mixture is treated with water and extracted with ether. The dried extracts are evaporated to yield 2,3-dihydroxypropyl 2-fluoro-4-(hexadecylamino)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333940 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-6299707ec6524895b0447a8da4f7973f |
| Source note | uspto-grants-1982_06 |