HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Hydroxypropyl 3-fluoro-4-(hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | Methyl 3-fluoro-4-(hexadecylamino)benzoate | HCID 20536536 | — |
| Product | 3-Hydroxypropyl 3-fluoro-4-(hexadecylamino)benzoate | HCID 20536465 | — |
Reaction Steps
A mixture of 2.25 g of methyl 3-fluoro-4-(hexadecylamino)benzoate, 280 mg of 1,3-propanediol and 1.37 g. of p-toluenesulfonic acid is heated at 180° C. for 18 hours and then is partitioned between ether and 3% aqueous sodium carbonate solution. The ether layer is separated, dried, and evaporated to yield 3-hydroxypropyl 3-fluoro-4-(hexadecylamino)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333940 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-f47dab4153c14b71ab5ae0d1beb68522 |
| Source note | uspto-grants-1982_06 |