HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Fluoro-4-(hexadecylamino)phenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Water ethanol | HCID 19096565 | — |
| Reactant | Ethyl 2-fluoro-4-(hexadecylamino)phenylacetate | HCID 54400635 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Fluoro-4-(hexadecylamino)phenylacetic acid | HCID 53893534 | — |
Reaction Steps
A mixture of 6.0 g. of ethyl 2-fluoro-4-(hexadecylamino)phenylacetate, 7.0 g. of potassium hydroxide and 100 ml. of ethanol-water is heated to reflux for 4 hours. While hot, the mixture is adjusted to pH 7 with conc. hydrochloric acid. The mixture is diluted with water, cooled and filtered. Recrystallization of the precipitate yields 2-fluoro-4-(hexadecylamino)phenylacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333940 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-e6ecb19250304498b971fc46e9106ff6 |
| Source note | uspto-grants-1982_06 |