HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 54401129, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Bromohexadecane | HCID 8213 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | HCID 53785318 | HCID 53785318 | — |
| Reactant | 2-Fluoro-4-nitrocinnamic acid | HCID 54424786 | — |
| Reactant | Ethyl 2-fluoro-4-(hexadecylamino)phenylpropiolate | HCID 54428487 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Ammonium Hydroxide | HCID 14923 | — |
| Product | HCID 54401129 | HCID 54401129 | — |
Reaction Steps
Alternatively, the 2-fluoro-4-aminophenylpropiolic acid is prepared from 2-fluoro-4-nitrocinnamic acid by successive treatment with bromine in acetic acid, aqueous sodium hydroxide, ferric sulfate and ammonium hydroxide, and ethanolic hydrogen chloride. The propiolic acid is then converted to the corresponding ethyl ester and alkylated with 1-bromohexadecane in the manner of Example 9. The resulting ethyl 2-fluoro-4-(hexadecylamino)phenylpropiolate is hydrolyzed in the manner of Example 10 to yield 2-fluoro-4-(hexadecylamino)phenylpropiolic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04333940 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-41e3248ec8a64d41a9f2e9dba3e75873 |
| Source note | uspto-grants-1982_06 |