Formaldehyde → HCID 13041086, compound

Participants

Reaction Steps

To 100 ml of methanol are added 19.8 g of 6-isopropyl-2-ethoxy-5-oxo-5,6-dihydro-2H-pyran, 7 g of 37% formalin and 9 g of morpholine. Then the mixture is stirred at room temperature for 4 hours. The reaction mixture is concentrated at reduced pressure and the residue is isolated and purified by silica gel column chromatography giving 23.6 g of light yellow oily 6-isopropyl-2-ethoxy-4-morpholinomethyl-5-oxo-5,6-dihydro-2H-pyran (compound No. 2 in Table 1). IR (neat)

Provenance & Evidence