HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → 10-Hydroxy-8-fluoro-dibenzo[b,f]thiepin-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 10-Hydroxy-8-fluoro-dibenzo[b,f]thiepin-3-carboxylic acid | HCID 20536993 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 10-Hydroxy-8-fluoro-dibenzo[b,f]thiepin-3-carboxylic acid methyl ester | HCID 70548842 | 78% |
Reaction Steps
10-Hydroxy-8-fluoro-dibenzo[b,f]thiepin-3-carboxylic acid (4 g; 13.8 mmoles) dissolved in methanol (100 mL) and treated with excess diazomethane in ether. The volatiles removed under vacuum and the residue, taken up in chloroform, is purified by chromatography in Silica Gel. Elution with 20% ethyl acetate in toluene yielded 3.26 g (78%) of the title compound, m.p. 85°-88° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04334077 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-d4e1d0a2e9894b4cb1b9ba607b28ebab |
| Source note | uspto-grants-1982_06 |