HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → methyl 10-Oxo-8-fluoro-dibenzo [b,f]thiepin-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 10-Oxo-8-fluoro-dibenzo[b,f]thiepin-3-carboxylic acid | HCID 13035106 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | methyl 10-Oxo-8-fluoro-dibenzo [b,f]thiepin-3-carboxylate | HCID 13035107 | 94% |
Reaction Steps
10-Oxo-8-fluoro-dibenzo[b,f]thiepin-3-carboxylic acid (2 g; 6.94 mmoles) is partially dissolved in methanol (20 mL) and is treated with excess diazomethane in ether. The resulting solution is evaporated to dryness, triturated in methanol to yield 1.98 g (94%) of methyl 10-Oxo-8-fluoro-dibenzo [b,f]thiepin-3-carboxylate, m.p. 129°-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04334077 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-66aae2deff6345efb79dd06b0b1fcb92 |
| Source note | uspto-grants-1982_06 |