Ammonia → HCID 73164534, compound

HRID 1156158Notes

Reaction equation

HRID 1156158 reaction equation
[N:1](=[C:3]([CH:6]([CH3:8])[CH3:7])[C:4]#N)[OH:2].[OH-:9].[Na+].N.[OH2:12]>>[N:1](=[C:3]([CH:6]([CH3:8])[CH3:7])[C:4]([OH:12])=[O:9])[OH:2]

Participants

5

Reactant 4

HCID 222AmmoniaHCID 962Water2×HCID 14798Sodium HydroxideHCID 73183566HCID 73183566, compound

Product 1

HCID 73164534HCID 73164534, compound

Procedure

A solution of 3.36 g of 2-oximino-3-methylbutyronitrile, 7 ml of 50% NaOH and 3 ml of water is refluxed under a slow stream of nitrogen until cessation of ammonia evolution. This is allowed to cool to RT. The mixture is then diluted with water and washed with ether to remove the neutrals. The aqueous layer is acidified (HCl) and extracted into ether to give 2-oximino-3-methylbutanoic acid, m.p.=153° (dec).

Workup

  1. washwashed with ether
  2. customto remove the neutrals
  3. extractionextracted into ether

Sources & evidence

ORD record
ord-f40244955b9e46c8acc240b9a28c86a0
Source dataset
uspto-grants-1982_06
Patent number
US04334087

Reaction notes

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