Hydrochloric Acid → HCID 53950405, compound

Participants

Reaction Steps

Using the method described by Papa et al. [J. Amer.Chem.Soc. 69 (1947), 3018], 12.3 g of azelaic acid ethyl ester chloride in 20 ml of chlorobenzene are mixed cold with 9.5 g of aluminium trichloride and the mixture is then heated at 150° overnight. After adding dilute hydrochloric acid to the complex, the organic phase is washed and concentrated; the residue is extracted with diethyl ether. After column chromatography, and concentration of the solution, 8.3 g of 9-(4-chlorophenyl)-9-oxo-nonanoic acid ethyl ester are obtained as a viscous oil.

Provenance & Evidence