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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156190Generated: November 3, 2026

3-Bromo-1-(trimethylsilyl)-1-propyne → Methyl [6,7-dichloro-1-oxo-2-phenyl-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate

https://huagongshe.com/reaction/1156190

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-1-(trimethylsilyl)-1-propyneHCID 642589—
ReactantMethyl (6,7-dichloro-1-oxo-2-phenyl-5-indanyloxy)acetateHCID 12774096—
SolventDichloromethane cyclohexaneHCID 21916607—
ProductMethyl [6,7-dichloro-1-oxo-2-phenyl-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetateHCID 1277409274%

Reaction Steps

Reaction of methyl (6,7-dichloro-1-oxo-2-phenyl-5-indanyloxy)acetate with 1-bromo-3-(trimethylsilyl)-2-propyne according to Example 1, STEP (b), affords the title compound, m.p. 125.5°-127° (from cyclohexane-methylene chloride) in 74% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04334088
Source datasetuspto-grants-1982_06
ORD IDord-821c80682b2a44e883a66372506427cb
Source noteuspto-grants-1982_06