Potassium Carbonate → HCID 20535634, compound

Participants

Reaction Steps

A mixture of ethyl 5-hydroxy-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate (2.2 g), 2-hydroxy propyl bromide (5 g), anhydrous potassium carbonate (5 g) and acetone (200 ml) was heated at reflux for 3 days. After cooling, the reaction mixture was filtered and the acetone removed from the filtrate in vacuo. The oily residue was dissolved in chloroform (100 ml) and the chloroform solution washed with 1 N aqueous sodium hydroxide solution (50 ml) and water (50 ml) and then dried. Removal of the chloroform in vacuo gave a brown solid which on crystallisation from ethanol gave ethyl 5-(2-hydroxypropoxy)-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate identical in all respects with authentic material.

Provenance & Evidence