HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 11-Cyano-11-[3-(dimethylamino)propyl]-6,11-dihydrodibenz[b,e]oxepin hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 12962160 | HCID 12962160 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 11-Cyano-11-[3-(dimethylamino)propyl]-6,11-dihydrodibenz[b,e]oxepin hydrochloride | HCID 20535779 | — |
Reaction Steps
A solution of 11-cyano-11-[3-(dimethylamino)propyl]-6,11-dihydrodibenz[b,e]oxepin of Example 4 (3.0 g; 0.009 mole) in dry ether is vigorously stirred and cooled in an ice bath. A saturated solution of HCl in ether is added dropwise until no more salt precipitates. The salt is filtered, washed with ether and dried. Two recrystallizations from methanol-ether provide 1.1 g of crystals of 11-cyano-11-[3-dimethylamino)propyl[-6,11-dihydrodibenz[b,e]oxepin hydrochloride, m.p. 219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04335122 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-c763d0905cb74307a4f5d2da93cb01c4 |
| Source note | uspto-grants-1982_06 |