HCID 12962152, compound → HCID 12962153, compound

Participants

Reaction Steps

2,11-Dichloro-6,11-dihydrodibenz[b,e]oxepin (7.7 g; 0.03 mole) of example 25-A is dissolved in dry toluene (120 ml) and placed under a positive dry nitrogen atmosphere. To this solution is added CuCN (5.2 g; 0.05 mole) in one portion and the reaction brought to reflux for 61/2 hours. The reaction mixture is filtered while hot (80° C.) and the salts washed with tolune. After removing the filtrate in vacuo the resulting solid is triturated with hexane and dried to yield 2-chloro-11-cyano-6,11-dihydrodibenz[b,e]oxepin, m.p. 113°-115° C.

Provenance & Evidence