HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 1-(3-chloropropyl)-2,3-dihydro-2,2-dimethyl-4(1H)-quinazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-[(3-Chloropropyl)amino]benzamide | HCID 19698346 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-chloropropyl)-2,3-dihydro-2,2-dimethyl-4(1H)-quinazolinone | HCID 20278942 | — |
Reaction Steps
A mixture of 10 parts of 2-[(3-chloropropyl)amino]benzamide, 16 parts of 2-propanone, 1 part of 4-methylbenzenesulfonic acid and 40 parts of ethanol is stirred and refluxed overnight. The reaction mixture is evaporated and the oily residue is stirred in 2,2'-oxybispropane. The product is filtered off and dried, yielding 10 parts of 1-(3-chloropropyl)-2,3-dihydro-2,2-dimethyl-4(1H)-quinazolinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04335127 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-59a11f4c179047c7bc16dd0bd9ffb495 |
| Source note | uspto-grants-1982_06 |