Hydrochloric Acid → HCID 13476527, compound

Participants

Reaction Steps

To a stirred mixture of 250 parts of pyridine and 39 parts of 6-fluoro-1H-indole are added dropwise 42 parts of benzoyl chloride at 22° C. Upon completion, stirring is continued for 2 hours at room temperature. The reaction mixture is diluted with water and a hydrochloric acid solution 2 N is added. The product is extracted twice with 350 parts of 1,1'-oxybisethane. The combined extracts are dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions are collected and the eluent is evaporated, yielding 95 parts of 1-benzoyl-4-(6-fluoro-1H-indol-3-yl)-1,4-dihydropyridine as an oily residue.

Provenance & Evidence