Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(2-chloroethyl)(1H,3H)quinazoline-2,4-dione | HCID 78766 | — |
| Reactant | 6-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11096077 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | HCID 13476529 | HCID 13476529 | — |
Reaction Steps
A mixture of 7.5 parts of 3-(2-chloroethyl)-2,4(1H,3H)-quinazolinedione, 6.8 parts of 6-fluoro-3-(4-piperidinyl)-1H-indole, 10 parts of sodium carbonate, 0.1 parts of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. Water is added and the layers are separated. The aqueous phase is set aside. The organic phase is dried, filtered and evaporated. The solid residue is boiled in 2-propanol. The product is filtered off and dried, yielding a first fraction of 4 parts of 3-[2-[4-(6-fluoro-1H-indol-3-yl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione. From the aqueous phase (see above), a solid product is filtered off and boiled in 2-propanol. The product is filtered off and dried, yielding a second fraction of 3 parts of 3-[2-[4-(6-fluoro-1H-indol-3-yl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione; mp. 300.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04335127 |
|---|
| Source dataset | uspto-grants-1982_06 |
|---|
| ORD ID | ord-4b0918a8c74d40bfa1c2dfb354b54f1d |
|---|
| Source note | uspto-grants-1982_06 |
|---|
