反应详情

To a stirred mixture of 15 parts of [1-(phenylmethyl)-4-piperidinyl] (2-thienyl)methanone in 120 parts of benzene are added dropwise 8 parts of ethyl carbonochloridate. Upon completion, the whole is heated to reflux and stirred for 6 hours at reflux temperature. The reaction mixture is cooled, filtered and evaporated, yielding 13 parts of ethyl 4-(2-thienylcarbonyl)-1-piperidinecarboxylate as a residue.

1. temperatureUpon completion, the whole is heated
2. temperatureto reflux
3. temperatureat reflux temperature
4. temperatureThe reaction mixture is cooled
5. filtrationfiltered
6. customevaporated