Hydrochloric Acid → HCID 10088282, compound

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Reaction Steps

In this example, 150 mg (0.45 mmole) of trifluoroacetate of (±)-cis-7-amino-3-chloro-1-azabicyclo[4,2,0]oct-2-en-8-on-2-carboxylic acid is suspended in a mixed solvent of 2 ml of water and 2 ml of acetone, 134 mg (1.5 mmole) of sodium bicarbonate is added thereto to make a homogeneous solution. To the solution is added dropwise a solution of 84.2 mg (0.54 mmole) of phenylacetyl chloride in 0.5 ml of acetone under ice cooling in one hour. The mixture is stirred for 3 hours, adjusted to pH 2 with 1 N hydrochloric acid and extracted 5 times with each 2 ml of ethyl acetate. The extract is concentrated under reduced pressure and the residue is dried to obtain 80 mg (55.0%) of the desired compound.

Provenance & Evidence