HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → HCID 12905997, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloropropanamide | HCID 94385 | — |
| Reactant | p-(4-(Trifluoromethyl)phenoxy)phenol | HCID 170230 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 12905997 | HCID 12905997 | — |
Reaction Steps
A mixture containing 10.0 g (0.039 mole) of 4-(4-trifluoromethylphenoxy)phenol, 5.0 g (0.039 mole) of 2-chloropropanamide, 6.9 g (0.05 mole) of anhydrous potassium carbonate, and 50 ml of dimethylsulfoxide is stirred at 90° until reaction is complete, as indicated by vpc techniques. The resultant slurry is cooled, poured into 600 ml of water, and teated with 1:1 hexane/tolune, and the product is isolated by filtration, mp 147°-149°. Recrystallization from hexane affords highly pure product, mp 149-151.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04335249 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-27d4d06f2325478681cdf4653af6726e |
| Source note | uspto-grants-1982_06 |