참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N,N-Dimethylbenzylamine | HCID 7681 | — |
| 반응물 | Acrylonitrile | HCID 7855 | — |
| 반응물 | 4-Bromobenzoyl chloride | HCID 68515 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | P-Xylene | HCID 7809 | — |
| 생성물 | 4-Bromocinnamonitrile | HCID 53480 | 67.3% |
반응 단계
54.88 g (0.25 mol) of 4-bromobenzoyl chloride, 20.81 ml (0.31 mol) of acrylonitrile and 37.65 ml (0.25 mol) of N-benzyldimethylamine are added to 0.561 g (2.5 millimols) of palladium acetate in 500 ml of p-xylene. The mixture is stirred for 1.5 hours at 120° C. The crude product is distilled and recrystallised from cyclohexanone. 35 g (67% of theory) of 4-bromocinnamonitrile are obtained in the form of white flakes; melting point 105.7° C. Analysis for C9H4NBr: calculated C 51.96%, H 2.91%, N 6.73%, Br 38.40%; found C 51.93%, H 3.01%, N 6.69%, Br 38.35%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04335054 |
|---|
| 출처 데이터셋 | uspto-grants-1982_06 |
|---|
| ORD ID | ord-97bbf48433274827836567a26694ad0a |
|---|
| 출처 메모 | uspto-grants-1982_06 |
|---|
