Dimethylamine → Isouron

HRID 1156478Notes

Reaction equation

HRID 1156478 reaction equation
[CH3:1][NH:2][CH3:3].[C:4]([C:8]1[O:12][N:11]=[C:10]([N:13]=[C:14]=[O:15])[CH:9]=1)([CH3:7])([CH3:6])[CH3:5]>C1C=CC=CC=1>[CH3:1][N:2]([CH3:3])[C:14]([NH:13][C:10]1[CH:9]=[C:8]([C:4]([CH3:7])([CH3:5])[CH3:6])[O:12][N:11]=1)=[O:15]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 129188385-Tert-butyl-3-isocyanato-1,2-oxazole

Product 1

HCID 41648Isouron

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

1,1-Dimethyl-3-(5-tert.-butyl-3-isoxazolyl)urea is prepared by condensing dimethylamine with 5-tert.-butyl-3-isoxazolyl isocyanate in benzene. After removal of the reaction solvent and purification by chromatography or crystallization, there is obtained 1,1-dimethyl-3-(5-tert.-butyl-3-isoxazolyl)urea. M.P. 119.5°-120.5° C.

Workup

  1. customAfter removal of the reaction solvent and purification
  2. customby chromatography or crystallization

Sources & evidence

ORD record
ord-9f4a274f50d34f6da48f1b5728fce7fa
Source dataset
uspto-grants-1982_06
Patent number
US04336056

Reaction notes

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