Water → HCID 13037479, compound

HRID 1156480Notes

Reaction equation

HRID 1156480 reaction equation
O.[OH-].[Na+].[CH3:4][CH:5]1[O:10][C:9]([CH2:18][NH2:19])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[CH2:8][CH2:7][O:6]1.[Cl:20][CH2:21][C:22](Cl)=[O:23]>ClCCl>[CH3:4][CH:5]1[O:10][C:9]([CH2:18][NH:19][C:22](=[O:23])[CH2:21][Cl:20])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[CH2:8][CH2:7][O:6]1

Participants

6

Reactant 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 13037478HCID 13037478, compound

Product 1

HCID 13037479HCID 13037479, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
5 °C

Procedure

Fifteen milliliters (ml) of water, 25 ml of dichloromethane, 4 ml (0.075 mole) of 50% sodium hydroxide and 7.2 grams (g) (0.03 mole) of 2-methyl-4-(aminomethyl)-4-(2-chlorophenyl)-1,3-dioxane were added to a reaction flask and cooled to 5° C. with an ice bath. Four and a half g of chloroacetyl chloride in 10 ml of dichloromethane were added at a rate slow enough to keep the temperature under 10° C. The reaction mixture was stirred for 1/2 hour and allowed to come to room temperature.

Workup

  1. customunder 10° C
  2. customto come to room temperature

Sources & evidence

ORD record
ord-51ceb8a336cd4ba49105f6e57e6adb19
Source dataset
uspto-grants-1982_06
Patent number
US04336058

Reaction notes

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