反应详情

A mixture of 3.5 g N-(thiazol-4-yl)methyl-2-ethyl-6-methylaniline (from Example 11) and 125 ml toluene was heated to reflux and 1.7 g chloroacetyl chloride was added dropwise. The mixture was refluxed for 2 hours, cooled, stripped and purified on a silica-gel column using methylene chloride followed by 2% methanol:methylene chloride. C15H17ClN2O5 : calc., %C 58.35,%H 5.51, %N, 9.08; found, %C 57.07, %H 5.58, %N 7.81.

1. temperaturewas heated
2. temperatureto reflux
3. temperatureThe mixture was refluxed for 2 hours
4. temperaturecooled
5. custompurified on a silica-gel column