Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1H-Pyrrole, 3-(phenylmethyl)- | HCID 11768828 | — |
| Catalyst | Potassium Carbonate | HCID 11430 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Benzyl-1-pyrrolylmethanol | HCID 54343081 | 97.3% |
Reaction Steps
2.18 g (13.9 mmole) of 3-benzylpyrrole, 0.42 g (13.9 mmole) of paraformaldehyde and 0.07 g (0.5 mmole) of anhydrous potassium carbonate are mixed and stirred at 50° C. for 4 hours in the an atmosphere of nitrogen. Dry tetrahydrofuran is added to the reaction solution and filtered. The filtrate is concentrated to obtain 2.53 g of 3-benzyl-1-pyrrolylmethanol as a pale yellow liquid. Yield 97.3%. nD31.5 1.5837.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04336194 |
|---|
| Source dataset | uspto-grants-1982_06 |
|---|
| ORD ID | ord-1d08cd8a9a804822b062c1a73e692879 |
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| Source note | uspto-grants-1982_06 |
|---|
