HCID 19887167, compound → HCID 178419720, compound

HRID 1156506Notes

Reaction equation

HRID 1156506 reaction equation
[Br:1][C:2]1[C:7]([NH2:8])=[C:6]([Br:9])[N:5]=[CH:4][N:3]=1.Cl[N:11]([C:13]1[N:18]=CC=C[N:14]=1)Cl>>[BrH:1].[NH2:8][C:7]1[C:2]([NH:14][C:13]([NH2:18])=[NH:11])=[N:3][CH:4]=[N:5][C:6]=1[Br:9]

Participants

3

Reactant 2

HCID 19887167HCID 19887167, compoundHCID 205347742383730-70-7

Product 1

HCID 178419720HCID 178419720, compound

Procedure

Repeating this reaction with 4,6-dibromo-5-aminopyrimidine prepared as is the dichloroaminopyrimidine gives 5-amino-6-bromo-4-guanidinopyrimidine hydrobromide. Other 6-halo congeners are made by variations of these reactions.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-a9f7d6c6fd464ca7a708ab0c585e03e6
Source dataset
uspto-grants-1982_06
Patent number
US04336255

Reaction notes

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