HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → 1-(1-Methyl-2-phenoxyethylamino)-3-(3-hydroxyphenoxy)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 1-Phenoxy-2-propanamine | HCID 37087 | — |
| Reactant | 3-(2,3-Epoxy-1-propoxy)-phenol | HCID 20534798 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(1-Methyl-2-phenoxyethylamino)-3-(3-hydroxyphenoxy)-2-propanol | HCID 12855737 | 38% |
Reaction Steps
A mixture of 1.66 g. (10 mmole) of 3-(2,3-epoxy-1-propoxy)-phenol and 4.5 g. (30 mmole) of 1-methyl-2-phenoxyethylamine was heated at 80° C. overnight. The mixture was taken up in ether, and hexane was added to precipitate the product. Recrystallization from ethyl acetate gave 1-(1-methyl-2-phenoxyethylamino)-3-(3-hydroxyphenoxy)-2-propanol (38%); mp 124°-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04336261 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-661f65f7a00540aa92488398a9300aed |
| Source note | uspto-grants-1982_06 |