Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Glycidol | HCID 11164 | — |
| Reactant | HCID 12851223 | HCID 12851223 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 12855751 | HCID 12855751 | — |
Reaction Steps
To 1,1-dimethyl-3-phenylpropylamine (3.6 g., 22 mmole) in 20 ml. 2-propanol at 50° C. in an oil bath was added glycidol (1.7 g., 23 mmole) in 10 ml. 2-propanol dropwise over 5-10 min. The mixture was heated at 75° C. for 2 hours. After evaporation of the solvent, vacuum distillation provided 3.9 g. (75%) of 3-(1,1-dimethyl-3-phenylpropylamino)-1,2-dihydroxypropane (bp 160°-180°/0.5 mm which crystallized upon standing (mp 74°-77° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04336261 |
|---|
| Source dataset | uspto-grants-1982_06 |
|---|
| ORD ID | ord-efee8ac98e8f436082c9ca37ad34aaee |
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| Source note | uspto-grants-1982_06 |
|---|
