反应详情

5-(4-(Trifluoromethyl)phenyl)-3-aminoisoxazole (500 grams) in 6 l. 1,2-dichloromethane was reacted in a reaction vessel with 2,6-dichlorobenzoyl isocyanate (567 grams). The isocyanate was added in rapid dropwise fashion over one hour keeping the temperature between 20°-40° C. The reaction mixture was allowed to react at 40° C. for three hours and was then stripped and slurried in 1 l. methanol. A white solid product formed which was filtered, dried in an air dryer, and then identified by NMR analysis as the desired compound, yield, 881 grams, m.p.=227°-230° C.

1. custombetween 20°-40° C
2. customto react at 40° C. for three hours
3. customA white solid product formed which
4. filtrationwas filtered
5. customdried in an air dryer
6. customyield