Sodium Methoxide → HCID 54142171, compound

HRID 1156526Notes

Reaction equation

HRID 1156526 reaction equation
[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([CH:7](Br)[CH:8](Br)[C:9]#[N:10])=[CH:3][CH:2]=1.[CH3:19][O-:20].[Na+]>CO>[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([C:7]([O:20][CH3:19])=[CH:8][C:9]#[N:10])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 12960029HCID 12960029, compound

Product 1

HCID 54142171HCID 54142171, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(4-Biphenylyl)-2,3-dibromopropionitrile (16 grams) and sodium methoxide (4.7 grams) in 500 ml. of methanol were reacted in an ice bath. A solid precipitated at once and then the reaction mixture was stirred for 2 hours. The final product was determined by NMR to be a mixture of 3-(4-biphenylyl)-3-methoxyacrylonitrile plus 3-(4-biphenylyl)-3,3-dimethoxypropionitrile.

Workup

  1. customA solid precipitated at once and then the reaction mixture
  2. additiona mixture of 3-(4-biphenylyl)-3-methoxyacrylonitrile plus 3-(4-biphenylyl)-3,3-dimethoxypropionitrile

Sources & evidence

ORD record
ord-63c256b94c184ff8a79dd37cac3572ab
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

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