Thionyl Chloride → HCID 15588907, compound

HRID 1156577Notes

Reaction equation

HRID 1156577 reaction equation
[CH2:1]([C:3]1[C:7]([C:8]2[NH:9][C:10]3[C:15]([C:16]=2[CH2:17][C:18](O)=[O:19])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[C:6]([CH3:21])[O:5][N:4]=1)[CH3:2].S(Cl)([Cl:24])=O>C1(C)C=CC=CC=1>[CH2:1]([C:3]1[C:7]([C:8]2[NH:9][C:10]3[C:15]([C:16]=2[CH2:17][C:18]([Cl:24])=[O:19])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[C:6]([CH3:21])[O:5][N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 12854869HCID 12854869, compound

Product 1

HCID 15588907HCID 15588907, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 10.3 g. (0.036 mole) 2-(3-ethyl-5-methyl-4-isoxazolyl)-3-indole acetic acid and 22.0 g. (0.185 mole) thionyl chloride in 100 ml. toluene is stirred at room temperature for 18 hours. The toluene is removed in vacuo to give 2-(3-ethyl-5-methyl-4-isoxazolyl)-3-indole acetyl chloride.

Workup

  1. additionA mixture of 10.3 g
  2. customThe toluene is removed in vacuo

Sources & evidence

ORD record
ord-f5693d0da9be407682b4c3802c9b4c0b
Source dataset
uspto-grants-1982_06
Patent number
US04336378

Reaction notes

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