Sodium Hydroxide → HCID 13037787, compound

Participants

Reaction Steps

There was dissolved in 15 ml of tetrahydrofuran and 3.75 ml of 2 N sodium hydroxide 1.09 g (3 mMol) of the ester product prepared in Step B above; and the reaction mixture was stirred overnight at room temperature, whereupon a solid precipitated. Then, 4 ml of 2 N hydrochloric acid was added, and the mixture was stirred well. The tetrahydrofuran layer was then separated, and the aqueous layer was extracted twice with 20 ml of diethyl ether. The combined organic layers were dried and evaporated. The oily residue solidified on standing. The material was crystallized from carbon tetrachloride, whereupon a yellow solid was obtained (370 mg), m.p. 133°-140° C. The material was crystallized again from carbon tetrachloride, m.p. 142°-144° C. Analysis:

Provenance & Evidence