1-(3,4-Dihydroxyphenyl)-2-((1,1-dimethylethyl)amino)ethan-1-one hydrochloride → 2,2-Dimethylvaleroyl chloride
Reaction equation
[ClH:1].C(NC[C:8]([C:10]1[CH:15]=[CH:14][C:13](O)=C(O)[CH:11]=1)=[O:9])(C)(C)C.[CH3:18][O-].[Na+].C1([O-])C=CC=CC=1.[Na+]>>[CH3:18][C:10]([CH3:11])([CH2:15][CH2:14][CH3:13])[C:8]([Cl:1])=[O:9]Participants
4
Procedure
Proceeding in a manner similar to that described in Example 2A above, 26 g. of 3,4-dihydroxyphenyl tert-butylaminomethyl ketone hydrochloride was interacted with 18 g. of sodium methoxide, and the resulting sodium phenolate salt was interacted with 30 ml. of 2,2-dimethylpentanoyl chloride to yield 17 g. of 3,4-bis(2,2-dimethylpentanoyloxy)phenyl tert-butylaminomethyl ketone hydrochloride as a white crystalline solid which melted at 183°-185° C. (uncorr.).
Sources & evidence
- ORD record
- ord-48787da87fa84369a893577d5740ba34
- Source dataset
- uspto-grants-1982_06
- Patent number
- US04336400
Reaction notes
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