HCID 12295044, compound → Ammonium Hydroxide

Participants

Reaction Steps

By catalytic hydrogenation of 15 g. of 3,4-bis(2,2-dimethylpentanoyloxy)phenyl tert-butylaminomethyl ketone hydrochloride in 200 ml. of 95 percent ethyl alcohol in the presence of 2 g. of 10 percent palladium-on-charcoal catalyst there was obtained 3,4-bis(2,2-dimethylpentanoyloxy)-alpha-(tert-butylaminomethyl)benzyl alcohol hydrochloride which by treatment with an excess of 10 percent ammonium hydroxide was converted to the free base (11 g.). This base was converted to its methanesulfonic acid salt (10 g.), a white crystalline powder which melted at 107°-109° C. (uncorr.). The methanesulfonate was soluble in water at 25° C. to the extent of at least 5 percent.

Provenance & Evidence