Cyclohexanecarbonyl chloride → HCID 57288531, compound

HRID 1156665Notes

Reaction equation

HRID 1156665 reaction equation
CC1(C)C(CC)CC1CC(Cl)=O.C1(C(Cl)=O)CCCCC1.[C:22]([NH:26][CH2:27][C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][C:37](=[O:47])[CH2:38][CH:39]2[CH2:42][CH:41]([CH2:43][CH3:44])[C:40]2([CH3:46])[CH3:45])=[C:32]([O:48][C:49](=[O:59])[CH2:50][CH:51]2[CH2:54][CH:53]([CH2:55][CH3:56])[C:52]2([CH3:58])[CH3:57])[CH:31]=1)=[O:29])([CH3:25])([CH3:24])[CH3:23]>>[CH3:58][C:52]1([CH3:57])[CH:53]([CH2:55][CH3:56])[CH2:54][CH:51]1[CH2:50][C:49]([O:48][C:32]1[CH:31]=[C:30]([CH:35]=[CH:34][C:33]=1[O:36][C:37](=[O:47])[CH2:38][CH:39]1[CH2:42][CH:41]([CH2:43][CH3:44])[C:40]1([CH3:46])[CH3:45])[CH:28]([OH:29])[CH2:27][NH:26][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:59]

Participants

4

Reactant 3

HCID 75938Cyclohexanecarbonyl chlorideHCID 12670790HCID 12670790, compoundHCID 57229074HCID 57229074, compound

Product 1

HCID 57288531HCID 57288531, compound

Procedure

When 2,2-dimethyl-3-ethylcyclobutaneacetyl chloride is substituted for the cyclohexanecarbonyl chloride in the procedure described in Example 15A above, the acylation product obtained is 3,4-bis(2,2-dimethyl-3-ethylcyclobutaneacetoxy)-phenyl tert-butylaminomethyl ketone; and when this product is catalytically hydrogenated using the procedure described in Example 15B above, there is obtained 3,4-bis(2,2-dimethyl-3-ethylcyclobutaneacetoxy)-alpha-(tert-butylaminomethyl)benzyl alcohol.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-96ecd5aee33049f990bd8345442aa2f0
Source dataset
uspto-grants-1982_06
Patent number
US04336400

Reaction notes

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