Cyclohexylacetyl chloride → HCID 57202461, compound

HRID 1156666Notes

Reaction equation

C1(CC(Cl)=O)CCCCC1.[C:11]([NH:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26](=[O:34])[CH2:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[C:21]([O:35][C:36](=[O:44])[CH2:37][CH:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)[CH:20]=1)=[O:18])([CH3:14])([CH3:13])[CH3:12]>>[CH:38]1([CH2:37][C:36]([O:35][C:21]2[CH:20]=[C:19]([CH:24]=[CH:23][C:22]=2[O:25][C:26](=[O:34])[CH2:27][CH:28]2[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]2)[CH:17]([OH:18])[CH2:16][NH:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:44])[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]1

Participants

Reactant 2

HCID 2757989Cyclohexylacetyl chloride

HCID 57087190HCID 57087190, compound

Product 1

HCID 57202461HCID 57202461, compound

Procedure

Following the procedure described above in Example 15A but using cyclohexaneacetyl chloride instead of cyclohexanecarbonyl chloride the acylation product obtained is 3,4-bis(cyclohexaneacetoxy)phenyl tert-butylaminomethyl ketone; and when this product is catalytically hydrogenated, using the procedure described above in Example 15B, there is obtained 3,4-bis(cyclohexaneacetoxy)-alpha-(tert-butylaminomethyl)benzyl alcohol.

Workup

customobtained

Sources & evidence

ORD record: ord-0fff1523929849a7901f05c64f2f6e9d
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04336400

Reaction notes

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