HCID 54271791, compound → HCID 57253777, compound

HRID 1156669Notes

Reaction equation

C1(CCC(Cl)=O)CCCCCC1.[C:13]([NH:17][CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28](=[O:38])[CH2:29][CH2:30][CH:31]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)=[C:23]([O:39][C:40](=[O:50])[CH2:41][CH2:42][CH:43]2[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)[CH:22]=1)=[O:20])([CH3:16])([CH3:15])[CH3:14]>>[CH:43]1([CH2:42][CH2:41][C:40]([O:39][C:23]2[CH:22]=[C:21]([CH:26]=[CH:25][C:24]=2[O:27][C:28](=[O:38])[CH2:29][CH2:30][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]2)[CH:19]([OH:20])[CH2:18][NH:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:50])[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1

Participants

Reactant 2

HCID 54271791HCID 54271791, compound

HCID 56980747HCID 56980747, compound

Product 1

HCID 57253777HCID 57253777, compound

Procedure

Following the procedure described above in Example 15A but using cycloheptanepropionyl chloride instead of cyclohexanecarbonyl chloride the acylation product obtained is 3,4-bis(cycloheptanepropionyloxy)phenyl tert-butylaminomethyl ketone; and when this product is catalytically hydrogenated, using the procedure described above in Example 15B, there is obtained 3,4-bis(cycloheptanepropionyloxy)-alpha-(tert-butylaminomethyl)benzyl alcohol.

Workup

customobtained

Sources & evidence

ORD record: ord-646bf0f07b2c4651a656c566cc7d42a4
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04336400

Reaction notes

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