HRID1156675

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78282

Benzoyl chloride, 3,4,5-trimethoxy-

C10H11ClO4

HCID4445035

Sodium phenolate

C6H5NaO

HCID10942334

Methanol, sodium salt

CH3NaO

结构：CC(C)(C)NCC(=O)c1ccc(OC(=O)C(C)(C)C)c(O)c1

HCID12295016

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)Oc2cc(C(=O)CNC(C)(C)C)ccc2OC(=O)C(C)(C)C)cc(OC)c1OC

HCID20535457

未命名化合物

PROCEDURE

实验过程

Following a procedure similar to that described in Example 30A above, when 3-hydroxy-4-(pivalyloxy)phenyl tert-butylaminomethyl ketone is interacted with one equivalent of sodium methoxide and the resulting sodium phenolate salt is reacted with 3,4,5-trimethoxybenzoyl chloride there is obtained 3-(3,4,5-trimethoxybenzoyloxy)-4-(pivalyloxy)phenyl tert-butylaminomethyl ketone which reacts with hydrochloric acid to yield the hydrochloride salt. When this hydrochloride is catalytically hydrogenated, using the procedure described above in Example 30B, there is obtained 3-(3,4,5-trimethoxybenzoyloxy)-4-(pivalyloxy)-alpha-(tert-butylaminomethyl)benzyl alcohol hydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e90f515015f47618b553a995f36a27b
来源数据集: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04336400
来源说明: uspto-grants-1982_06

反应 SMILES

[C:1]([NH:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16](=[O:21])[C:17]([CH3:20])([CH3:19])[CH3:18])=[C:11]([OH:22])[CH:10]=1)=[O:8])([CH3:4])([CH3:3])[CH3:2].C[O-].[Na+].C1([O-])C=CC=CC=1.[Na+].[CH3:34][O:35][C:36]1[CH:37]=[C:38]([CH:42]=[C:43]([O:47][CH3:48])[C:44]=1[O:45][CH3:46])[C:39](Cl)=[O:40]>>[C:1]([NH:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16](=[O:21])[C:17]([CH3:20])([CH3:19])[CH3:18])=[C:11]([O:22][C:39](=[O:40])[C:38]2[CH:37]=[C:36]([O:35][CH3:34])[C:44]([O:45][CH3:46])=[C:43]([O:47][CH3:48])[CH:42]=2)[CH:10]=1)=[O:8])([CH3:4])([CH3:2])[CH3:3]