Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenolate Sodium → 3-(1,3-Dimethylcyclobutanecarbonyloxy)-4-(isovaleryloxy)phenyl tert-butylaminomethyl ketone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenolate Sodium | HCID 4445035 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 3-Hydroxy-4-(isovaleryloxy)phenyl tert-butylaminomethyl ketone | HCID 12295018 | — |
| 반응물 | 1,3-Dimethylcyclobutanecarbonyl chloride | HCID 20535379 | — |
| 생성물 | 3-(1,3-Dimethylcyclobutanecarbonyloxy)-4-(isovaleryloxy)phenyl tert-butylaminomethyl ketone | HCID 20535395 | — |
반응 단계
Following a procedure similar to that described in Example 13A above, when 3-hydroxy-4-(isovaleryloxy)phenyl tert-butylaminomethyl ketone is interacted with one equivalent of sodium methoxide and the resulting sodium phenolate salt is reacted with 1,3-dimethylcyclobutanecarbonyl chloride there is obtained 3-(1,3-dimethylcyclobutanecarbonyloxy)-4-(isovaleryloxy)-phenyl tert-butylaminomethyl ketone which reacts with hydrochloric acid to yield the hydrochloric salt. When this hydrochloride is catalytically hydrogenated, using the procedure described above in Example 13B, there is obtained 3-(1,3-dimethylcyclobutanecarbonyloxy)-4-(isovaleryloxy)-alpha-(tert-butylaminomethyl)-benzyl alcohol hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04336400 |
| 출처 데이터셋 | uspto-grants-1982_06 |
| ORD ID | ord-211613bd4b2b44cfa19f317a82cc5842 |
| 출처 메모 | uspto-grants-1982_06 |