HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156716Generated: October 25, 2026
Benzoyl chloride → 5-Benzamido-3-Trichloromethyl-1,2,4-Thiadiazole
https://huagongshe.com/reaction/1156716
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 5-Benzamido-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 12851601 | 85% |
Reaction Steps
A solution of 10.9 grams (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 14.1 grams (0.1 mole) benzoyl chloride in 200 milliliters xylene was refluxed at about 140° C. for 20 hours. Upon cooling the reaction mixture to -10° C., 13.7 grams (85% yield) pure product precipitated; m.p. 190.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04337081 |
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| Source dataset | uspto-grants-1982_06 |
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| ORD ID | ord-1defb461d5e74d5992f4e26ae66bf814 |
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| Source note | uspto-grants-1982_06 |
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