Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 12851605 | HCID 12851605 | 91% |
Reaction Steps
A solution of 21.8 grams (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 18.5 grams (0.2 mole) propionyl chloride in 300 milliliters toluene was refluxed at about 110° C. for 14 hours. The product precipitated (18.4 grams, 91% yield) upon cooling to -15° C. and was isolated by filtration. A pure product of m.p. 150.0° C. was obtained by recrystallization from cyclohexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04337081 |
|---|
| Source dataset | uspto-grants-1982_06 |
|---|
| ORD ID | ord-9a085f2247e64368b3a73f1d36bcaf7e |
|---|
| Source note | uspto-grants-1982_06 |
|---|
