Hydroxyamine hydrochloride → HCID 136061479, compound

Participants

Reaction Steps

Metallic sodium (0.55 g) was dissolved in methanol (40 ml) to prepare a methanolic solution of sodium methoxide. 5-Methylthio-2,3-dihydro-1,2,4-triazin-3-one (2.86 g) and hydroxylamine hydrochloride (1.67 g) were added thereto, and the resultant mixture was heated with reflux for 7 hours. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The concentrated residue was recrystallized from 30% aqueous ethanol to give 5-hydroxyamino-3-oxo-2,3-dihydro-1,2,4-triazine (Ic) (2.32 g) as pale yellow crystals. Yield, 90.6%. M.P., 270° C.

Provenance & Evidence