HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → HCID 13318566, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Methyl 3-bromopyrazine-2-carboxylate | HCID 13318551 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 13318566 | HCID 13318566 | — |
Reaction Steps
A mixture of 21.7 g 3-bromo-pyrazine-2-carboxylic acid methyl ester and 25.5 g 4-chloroaniline in 150 ml ethyl acetate is boiled 4 days at reflux. The solution is washed with 4 N hydrochloric acid, water and then with 2 N sodium carbonate. The organic phase is dried over sodium sulphate and evaporated to give the heading compound (recrystallised from isopropanol) m.p. 135°-136°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337198 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-22b57c85d076457ab472d62ee6371399 |
| Source note | uspto-grants-1982_06 |