HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156811Generated: November 1, 2026
Triethylamine → (S)-7-[[Ethoxy(4-phenylbutyl)phosphinyl]acetyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
https://huagongshe.com/reaction/1156811
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | [Ethoxy(4-phenylbutyl)phosphoryl]acetic acid | HCID 13136848 | — |
| Reactant | 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride | HCID 45358002 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-7-[[Ethoxy(4-phenylbutyl)phosphinyl]acetyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid | HCID 54496794 | 96.5% |
Reaction Steps
A mixture of 2.0 g of [ethoxy(4-phenylbutyl)phosphinyl]acetic acid and 1.1 g of carbonyldiimidazole in acetonitrile is stirred under argon at 0° C. for 1 hour and then treated with 1.9 g of triethylamine and 1.7 g of 1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride. After 4.5 hours the acetonitrile is stripped and the residue is partitioned between ethyl acetate and 1 N HCl. The organic phase is washed with brine, dried (MgSO4), and the solvent is stripped to give 3.2 g of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04337201 |
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| Source dataset | uspto-grants-1982_06 |
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| ORD ID | ord-98de4ab916994ecebe4e1163a89c2506 |
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| Source note | uspto-grants-1982_06 |
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